Search results for "PD model"
showing 6 items of 6 documents
Partial discharges behavior under different rectified waveforms
2017
In this work, a previous software used to simulate partial discharges (PDs) under Alternating Current (AC) stress has been modified in order to evaluate the PDs behavior under a voltage stress close to the Direct Current (DC) waveform. By using a full-wave and a half-wave rectifier, the specimen with an air void defects has been subjected to a gradual constant stress. Finally, a capacitive filter has been inserted in order to produce a steadier voltage supply. Simulation results show that under an almost DC waveform, the PDs activity become less compared to AC stress.
The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives
2021
Immuno-oncology (IO) focuses on the ability of the immune system to detect and eliminate cancer cells. Since the approval of the first immune checkpoint inhibitor, immunotherapies have become a major player in oncology treatment and, in 2021, represented the highest number of approved drugs in the field. In spite of this, there is still a fraction of patients that do not respond to these therapies and develop resistance mechanisms. In this sense, mathematical models offer an opportunity to identify predictive biomarkers, optimal dosing schedules and rational combinations to maximize clinical response. This work aims to outline the main therapeutic targets in IO and to provide a description …
Partial discharge behavior under single phase half and full-bridge rectifier
2017
The aim of the present work is to simulate partial discharges (PDs) phenomena under voltage stress close to the Direct Current (DC) waveform. The employed waveforms have been realized by using a full-wave and a half-wave rectifiers. After that, in order to generate a steadier voltage supply, a capacitive filter has been inserted in the output of the half-wave rectifier. Simulations have been carried out by modifying a previous software used in the case of Alternating Current (AC). Finally, experimental tests have been carried out in order to validate simulation results.
A modelling population-based approach to the effect of granulocyte growth factors during chemotherapy-induced neutropenia
2020
The work of this thesis is based on results of a cohort study whose main objective was to define the optimal schedule of prophylactic administration of granulocyte growth factors (G-CSF) in the context of FOLFIRINOX treatment. For this purpose, a pharmacokinetic/pharmacodynamic (PK/PD) model was built to describe the absolute neutrophil counts (ANC) time course in our population, including the three chemotherapies neutropenic effect, but also the stimulating effect of exogenous G-CSF on the proliferation and maturation of neutrophils. Based on the estimates of the model parameters, simulations were performed to determine the incidence and duration of neutropenia for each prophylactic G-CSF …
Simplified Hybrid PD Model in Voids
2011
In this paper a novel approach to model partial discharges (PD) activity taking place inside a spherical void in epoxy resin system has been traced. The approach is based on a time varying conductance of the inner void, subjected to multistress conditions: voltage, temperature and pressure. A simple lumped circuit macro-model simulates the global effects of PD activity: the different parameters influencing the discharge phenomenon in the void are taking into account by using a physical approach resulting in a time varying conductance inside the circuit. The evaluated PD activity has been compared with experimental and simulated one for the accessible and inaccessible part of the system. A d…
Simplified hybrid PD model in voids: Pattern validation
2013
The purpose of the present work is to show the validation of a new model to simulate the physical phenomenon of partial discharge (PD) produced in air voids inside insulating epoxy resin. The model has been developed on the basis of a new approach that combines the known circuit model of three capacitors with a model used to describe the behavior of the ionized channel inside of the inclusion during the discharge phenomenon, short-circuiting the capacity that represents the void. The approach is based on time-variable conductance of the void, subjected to multistress conditions: voltage, temperature and pressure. The new approach has been developed from a time variable conductivity model us…